毛自朝-农学与生物技术学院

姓名	毛自朝	所在系（室）	生物技术系
职务	无	职称	教授
学历/学位	博士	导师类别	博士、硕士研究生导师
电子邮箱	zmao@ynau.edu.cn
研究方向	作物基因组学和和分子生物学的教学与研究
教育经历和工作经历	云南省技术创新人才，全国农业生物化学与分子生物学学会农业分会理事，中国园艺学会芦笋分会理事，云南省高等学校大学课程教学指导委员会成员，云南农业大学特色小宗作物研究中心主任。教育经历： (1) 1999-09 至 2002-07, 北京大学, 植物学, 博士 (2) 1992-09 至 1995-07, 中国科学院昆明植物研究所, 植物学, 硕士 (3) 1988-09 至 1992-07, 兰州大学, 植物学, 学士博士后工作经历： (1) 2004-09 至 2009-09, 分别在美国弗吉尼亚联邦大学（VCU）和佐治亚理工大学 (GIT)从事基因代谢工程方面的博士后研究科研与学术工作经历（博士后工作经历除外）： (1) 2010-10 至今, 云南农业大学, 农学与生物技术学院, 教授 (2) 2002-10 至 2010-10, 云南农业大学, 农学与生物技术学院, 副教授 (3) 1997-10 至 2002-10, 云南农业大学, 农学与生物技术学院, 讲师 (4) 1995-07 至 1997-10, 云南农业大学, 农学与生物技术学院, 助教
教学情况和科研情况	承担研究生《组学与数据分析》和《分子生物学与基因组学》、本科生《基因组学》、《专业英语》等课程的教学任务。主要从事植物基因组和分子生物学的研究。主持国家基金项目2项；国家中小企业创新基金1项；国际合作项目、省级及其他项目等20项;发表论文100余篇，其种SCI论文20余篇。较系统地从欧美引进芦笋品种和资源100余份，在云南开展芦笋周年生产的种质创新、育种和产业化示范种植与加工研究，示范推广3万余亩，云南农业大学2017年获云南省芦笋引智示范单位。从南美安第斯山区域国家引进藜麦及近缘品种与种质资源300余份，开展育种研究及滇西北和滇东北高海拔(2400m以上)春夏季(原产地冷凉)和秋冬季(2000m以下)规模化推广藜麦种植5万余亩；主导或参与芦笋、藜麦、番茄等作物的选育新品种8个；授权专利17项，其中发明专利6项。培养毕业硕、博研究生30余人。
代表性成果	1. Li X, Li M, Mao Z, Du Y, Brown S, Min X, Zhang R, Zhong Y, Dong Y, Liu Z, Lin C. Identification of Bioactive Components of Stephania epigaea Lo and Their Potential Therapeutic Targets by UPLC-MS/MS and Network Pharmacology. Evid Based Complement Alternat Med. 2022;2022:3641586. doi: 10.1155/2022/3641586. eCollection 2022. PubMed PMID: 35529936; PubMed Central PMCID: PMC9068296. 2. Yang Z, Liu G, Zhang G, Yan J, Dong Y, Lu Y, Fan W, Hao B, Lin Y, Li Y, Li X, Tang Q, Xiang G, He S, Chen J, Chen W, Xu Z, Mao Z, Duan S, Jin S, Yang S. The chromosome-scale high-quality genome assembly of Panax notoginseng provides insight into dencichine biosynthesis. Plant Biotechnol J. 2021 May;19(5):869-871. doi: 10.1111/pbi.13558. Epub 2021 Feb 14. PubMed PMID: 33529371; PubMed Central PMCID: PMC8131050. 3. Zhang G, Mao Z, Wang Q, Song J, Nie X, Wang T, Zhang H, Guo H. Comprehensive transcriptome profiling and phenotyping of rootstock and scion in a tomato/potato heterografting system. Physiol Plant. 2019 Jul;166(3):833-847. doi: 10.1111/ppl.12858. Epub 2018 Nov 15. PubMed PMID: 30357855. 4. Harkess A, Zhou J, Xu C, Bowers JE, Van der Hulst R, Ayyampalayam S, Mercati F, Riccardi P, McKain MR, Kakrana A, Tang H, Ray J, Groenendijk J, Arikit S, Mathioni SM, Nakano M, Shan H, Telgmann-Rauber A, Kanno A, Yue Z, Chen H, Li W, Chen Y, Xu X, Zhang Y, Luo S, Chen H, Gao J, Mao Z, Pires JC, Luo M, Kudrna D, Wing RA, Meyers BC, Yi K, Kong H, Lavrijsen P, Sunseri F, Falavigna A, Ye Y, Leebens-Mack JH, Chen G. The asparagus genome sheds light on the origin and evolution of a young Y chromosome. Nat Commun. 2017 Nov 2;8(1):1279. doi: 10.1038/s41467-017-01064-8. PubMed PMID: 29093472; PubMed Central PMCID: PMC5665984. 5. Anane RF, Sun H, Zhao L, Wang L, Lin C, Mao Z. Improved curdlan production with discarded bottom parts of Asparagus spear. Microb Cell Fact. 2017 Apr 7;16(1):59. doi: 10.1186/s12934-017-0671-3. PubMed PMID: 28388915; PubMed Central PMCID: PMC5384130. 6. Li XM, Cai JL, Wang L, Wang WX, Ai HL, Mao ZC. Two new phenolic compounds and antitumor activities of asparinin A from Asparagus officinalis. J Asian Nat Prod Res. 2017 Feb;19(2):164-171. doi: 10.1080/10286020.2016.1206529. Epub 2016 Sep 13. PubMed PMID: 27618876. 7. Li XM, Cai JL, Wang WX, Ai HL, Mao ZC. Two new acetylenic compounds from Asparagus officinalis. J Asian Nat Prod Res. 2016;18(4):344-8. doi: 10.1080/10286020.2015.1082549. Epub 2015 Nov 11. PubMed PMID: 26558641. 8. Yu X, Zhang C, Yang L, Zhao L, Lin C, Liu Z, Mao Z. CrdR function in a curdlan-producing Agrobacterium sp. ATCC31749 strain. BMC Microbiol. 2015 Feb 10;15:25. doi: 10.1186/s12866-015-0356-1. PubMed PMID: 25880528; PubMed Central PMCID: PMC4327974. 9. Li XY, Yang JJ, Mao ZC, Ho HH, Wu YX, He YQ. Enhancement of Biocontrol Activities and Cyclic Lipopeptides Production by Chemical Mutagenesis of Bacillus subtilis XF-1, a Biocontrol Agent of Plasmodiophora brassicae and Fusarium solani. Indian J Microbiol. 2014 Dec;54(4):476-9. doi: 10.1007/s12088-014-0471-y. Epub 2014 May 23. PubMed PMID: 25320450; PubMed Central PMCID: PMC4186944. 10. Rutter C, Mao Z, Chen R. Periplasmic expression of a Saccharophagus cellodextrinase enables E. coli to ferment cellodextrin. Appl Microbiol Biotechnol. 2013 Sep;97(18):8129-38. doi: 10.1007/s00253-012-4646-3. Epub 2013 Jan 10. PubMed PMID: 23306638. 11. Chen RR, Agrawal M, Mao Z. Impact of expression of EMP enzymes on glucose metabolism in Zymomonas mobilis. Appl Biochem Biotechnol. 2013 Jun;170(4):805-18. doi: 10.1007/s12010-013-0239-6. Epub 2013 Apr 24. PubMed PMID: 23613118. 12. Guo S, Mao Z, Wu Y, Hao K, He P, He Y. Genome Sequencing of Bacillus subtilis Strain XF-1 with High Efficiency in the Suppression of Plasmodiophora brassicae. Genome Announc. 2013 Apr 4;1(2):e0006613. doi: 10.1128/genomeA.00066-13. PubMed PMID: 23558530; PubMed Central PMCID: PMC3622977. 13. Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. Diversity and active mechanism of fengycin-type cyclopeptides from Bacillus subtilis XF-1 against Plasmodiophora brassicae. J Microbiol Biotechnol. 2013 Mar;23(3):313-21. doi: 10.4014/jmb.1208.08065. PubMed PMID: 23462003. 14. He P, Hao K, Blom J, Rückert C, Vater J, Mao Z, Wu Y, Hou M, He P, He Y, Borriss R. Genome sequence of the plant growth promoting strain Bacillus amyloliquefaciens subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary metabolites. J Biotechnol. 2012 Dec 15;164(2):281-91. doi: 10.1016/j.jbiotec.2012.12.014. Epub 2013 Jan 26. PubMed PMID: 23357245. 15 . Hao K, He P, Blom J, Rueckert C, Mao Z, Wu Y, He Y, Borriss R. The genome of plant growth-promoting Bacillus amyloliquefaciens subsp. plantarum strain YAU B9601-Y2 contains a gene cluster for mersacidin synthesis. J Bacteriol. 2012 Jun;194(12):3264-5. doi: 10.1128/JB.00545-12. PubMed PMID: 22628498; PubMed Central PMCID: PMC3370840. 16. McClendon SD, Mao Z, Shin HD, Wagschal K, Chen RR. Designer xylanosomes: protein nanostructures for enhanced xylan hydrolysis. Appl Biochem Biotechnol. 2012 Jun;167(3):395-411. doi: 10.1007/s12010-012-9680-1. Epub 2012 May 4. PubMed PMID: 22555497. 17. Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. ESI LC-MS and MS/MS characterization of antifungal cyclic lipopeptides produced by Bacillus subtilis XF-1. J Mol Microbiol Biotechnol. 2012;22(2):83-93. doi: 10.1159/000338530. Epub 2012 May 16. PubMed PMID: 22614917. 18. Agrawal M, Mao Z, Chen RR. Adaptation yields a highly efficient xylose-fermenting Zymomonas mobilis strain. Biotechnol Bioeng. 2011 Apr;108(4):777-85. doi: 10.1002/bit.23021. Epub 2010 Dec 22. PubMed PMID: 21404252. Liang Y, Li X, Shin H, Chen RR, Mao Z. Expression and characterization of a xylosidase (Bxyl) from Bacillus halodurans C-125. Sheng Wu Gong Cheng Xue Bao. 2009 Sep;25(9):1386-93. PubMed PMID: 19938483. 19. Mao Z, Shin HD, Chen R. A recombinant E. coli bioprocess for hyaluronan synthesis. Appl Microbiol Biotechnol. 2009 Aug;84(1):63-9. doi: 10.1007/s00253-009-1963-2. Epub 2009 Mar 24. PubMed PMID: 19308402. 20. Mao Z, Chen RR. Recombinant synthesis of hyaluronan by Agrobacterium sp. Biotechnol Prog. 2007 Sep-Oct;23(5):1038-42. doi: 10.1021/bp070113n. Epub 2007 Aug 18. PubMed PMID: 17705506. 21. Ni Y, Mao Z, Chen RR. Outer membrane mutation effects on UDP-glucose permeability and whole-cell catalysis rate. Appl Microbiol Biotechnol. 2006 Nov;73(2):384-93. doi: 10.1007/s00253-006-0485-4. Epub 2006 Sep 27. PubMed PMID: 17004054. Ruffing A, Mao Z, Ruizhen Chen R. Metabolic engineering of Agrobacterium sp. for UDP-galactose regeneration and oligosaccharide synthesis. Metab Eng. 2006 Sep;8(5):465-73. doi: 10.1016/j.ymben.2006.05.004. Epub 2006 Jun 7. PubMed PMID: 16890004. 22. Mao Z, Shin HD, Chen RR. Engineering the E. coli UDP-glucose synthesis pathway for oligosaccharide synthesis. Biotechnol Prog. 2006 Mar-Apr;22(2):369-74. doi: 10.1021/bp0503181. PubMed PMID: 16599548.

姓名	毛自朝	所在系（室）	生物技术系
职务	无	职称	教授
学历/学位	博士	导师类别	博士、硕士研究生导师
电子邮箱	zmao@ynau.edu.cn
研究方向	作物基因组学和和分子生物学的教学与研究
教育经历和工作经历	云南省技术创新人才，全国农业生物化学与分子生物学学会农业分会理事，中国园艺学会芦笋分会理事，云南省高等学校大学课程教学指导委员会成员，云南农业大学特色小宗作物研究中心主任。教育经历： (1) 1999-09 至 2002-07, 北京大学, 植物学, 博士 (2) 1992-09 至 1995-07, 中国科学院昆明植物研究所, 植物学, 硕士 (3) 1988-09 至 1992-07, 兰州大学, 植物学, 学士博士后工作经历： (1) 2004-09 至 2009-09, 分别在美国弗吉尼亚联邦大学（VCU）和佐治亚理工大学 (GIT)从事基因代谢工程方面的博士后研究科研与学术工作经历（博士后工作经历除外）： (1) 2010-10 至今, 云南农业大学, 农学与生物技术学院, 教授 (2) 2002-10 至 2010-10, 云南农业大学, 农学与生物技术学院, 副教授 (3) 1997-10 至 2002-10, 云南农业大学, 农学与生物技术学院, 讲师 (4) 1995-07 至 1997-10, 云南农业大学, 农学与生物技术学院, 助教
教学情况和科研情况	承担研究生《组学与数据分析》和《分子生物学与基因组学》、本科生《基因组学》、《专业英语》等课程的教学任务。主要从事植物基因组和分子生物学的研究。主持国家基金项目2项；国家中小企业创新基金1项；国际合作项目、省级及其他项目等20项;发表论文100余篇，其种SCI论文20余篇。较系统地从欧美引进芦笋品种和资源100余份，在云南开展芦笋周年生产的种质创新、育种和产业化示范种植与加工研究，示范推广3万余亩，云南农业大学2017年获云南省芦笋引智示范单位。从南美安第斯山区域国家引进藜麦及近缘品种与种质资源300余份，开展育种研究及滇西北和滇东北高海拔(2400m以上)春夏季(原产地冷凉)和秋冬季(2000m以下)规模化推广藜麦种植5万余亩；主导或参与芦笋、藜麦、番茄等作物的选育新品种8个；授权专利17项，其中发明专利6项。培养毕业硕、博研究生30余人。
代表性成果	1. Li X, Li M, Mao Z, Du Y, Brown S, Min X, Zhang R, Zhong Y, Dong Y, Liu Z, Lin C. Identification of Bioactive Components of Stephania epigaea Lo and Their Potential Therapeutic Targets by UPLC-MS/MS and Network Pharmacology. Evid Based Complement Alternat Med. 2022;2022:3641586. doi: 10.1155/2022/3641586. eCollection 2022. PubMed PMID: 35529936; PubMed Central PMCID: PMC9068296. 2. Yang Z, Liu G, Zhang G, Yan J, Dong Y, Lu Y, Fan W, Hao B, Lin Y, Li Y, Li X, Tang Q, Xiang G, He S, Chen J, Chen W, Xu Z, Mao Z, Duan S, Jin S, Yang S. The chromosome-scale high-quality genome assembly of Panax notoginseng provides insight into dencichine biosynthesis. Plant Biotechnol J. 2021 May;19(5):869-871. doi: 10.1111/pbi.13558. Epub 2021 Feb 14. PubMed PMID: 33529371; PubMed Central PMCID: PMC8131050. 3. Zhang G, Mao Z, Wang Q, Song J, Nie X, Wang T, Zhang H, Guo H. Comprehensive transcriptome profiling and phenotyping of rootstock and scion in a tomato/potato heterografting system. Physiol Plant. 2019 Jul;166(3):833-847. doi: 10.1111/ppl.12858. Epub 2018 Nov 15. PubMed PMID: 30357855. 4. Harkess A, Zhou J, Xu C, Bowers JE, Van der Hulst R, Ayyampalayam S, Mercati F, Riccardi P, McKain MR, Kakrana A, Tang H, Ray J, Groenendijk J, Arikit S, Mathioni SM, Nakano M, Shan H, Telgmann-Rauber A, Kanno A, Yue Z, Chen H, Li W, Chen Y, Xu X, Zhang Y, Luo S, Chen H, Gao J, Mao Z, Pires JC, Luo M, Kudrna D, Wing RA, Meyers BC, Yi K, Kong H, Lavrijsen P, Sunseri F, Falavigna A, Ye Y, Leebens-Mack JH, Chen G. The asparagus genome sheds light on the origin and evolution of a young Y chromosome. Nat Commun. 2017 Nov 2;8(1):1279. doi: 10.1038/s41467-017-01064-8. PubMed PMID: 29093472; PubMed Central PMCID: PMC5665984. 5. Anane RF, Sun H, Zhao L, Wang L, Lin C, Mao Z. Improved curdlan production with discarded bottom parts of Asparagus spear. Microb Cell Fact. 2017 Apr 7;16(1):59. doi: 10.1186/s12934-017-0671-3. PubMed PMID: 28388915; PubMed Central PMCID: PMC5384130. 6. Li XM, Cai JL, Wang L, Wang WX, Ai HL, Mao ZC. Two new phenolic compounds and antitumor activities of asparinin A from Asparagus officinalis. J Asian Nat Prod Res. 2017 Feb;19(2):164-171. doi: 10.1080/10286020.2016.1206529. Epub 2016 Sep 13. PubMed PMID: 27618876. 7. Li XM, Cai JL, Wang WX, Ai HL, Mao ZC. Two new acetylenic compounds from Asparagus officinalis. J Asian Nat Prod Res. 2016;18(4):344-8. doi: 10.1080/10286020.2015.1082549. Epub 2015 Nov 11. PubMed PMID: 26558641. 8. Yu X, Zhang C, Yang L, Zhao L, Lin C, Liu Z, Mao Z. CrdR function in a curdlan-producing Agrobacterium sp. ATCC31749 strain. BMC Microbiol. 2015 Feb 10;15:25. doi: 10.1186/s12866-015-0356-1. PubMed PMID: 25880528; PubMed Central PMCID: PMC4327974. 9. Li XY, Yang JJ, Mao ZC, Ho HH, Wu YX, He YQ. Enhancement of Biocontrol Activities and Cyclic Lipopeptides Production by Chemical Mutagenesis of Bacillus subtilis XF-1, a Biocontrol Agent of Plasmodiophora brassicae and Fusarium solani. Indian J Microbiol. 2014 Dec;54(4):476-9. doi: 10.1007/s12088-014-0471-y. Epub 2014 May 23. PubMed PMID: 25320450; PubMed Central PMCID: PMC4186944. 10. Rutter C, Mao Z, Chen R. Periplasmic expression of a Saccharophagus cellodextrinase enables E. coli to ferment cellodextrin. Appl Microbiol Biotechnol. 2013 Sep;97(18):8129-38. doi: 10.1007/s00253-012-4646-3. Epub 2013 Jan 10. PubMed PMID: 23306638. 11. Chen RR, Agrawal M, Mao Z. Impact of expression of EMP enzymes on glucose metabolism in Zymomonas mobilis. Appl Biochem Biotechnol. 2013 Jun;170(4):805-18. doi: 10.1007/s12010-013-0239-6. Epub 2013 Apr 24. PubMed PMID: 23613118. 12. Guo S, Mao Z, Wu Y, Hao K, He P, He Y. Genome Sequencing of Bacillus subtilis Strain XF-1 with High Efficiency in the Suppression of Plasmodiophora brassicae. Genome Announc. 2013 Apr 4;1(2):e0006613. doi: 10.1128/genomeA.00066-13. PubMed PMID: 23558530; PubMed Central PMCID: PMC3622977. 13. Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. Diversity and active mechanism of fengycin-type cyclopeptides from Bacillus subtilis XF-1 against Plasmodiophora brassicae. J Microbiol Biotechnol. 2013 Mar;23(3):313-21. doi: 10.4014/jmb.1208.08065. PubMed PMID: 23462003. 14. He P, Hao K, Blom J, Rückert C, Vater J, Mao Z, Wu Y, Hou M, He P, He Y, Borriss R. Genome sequence of the plant growth promoting strain Bacillus amyloliquefaciens subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary metabolites. J Biotechnol. 2012 Dec 15;164(2):281-91. doi: 10.1016/j.jbiotec.2012.12.014. Epub 2013 Jan 26. PubMed PMID: 23357245. 15 . Hao K, He P, Blom J, Rueckert C, Mao Z, Wu Y, He Y, Borriss R. The genome of plant growth-promoting Bacillus amyloliquefaciens subsp. plantarum strain YAU B9601-Y2 contains a gene cluster for mersacidin synthesis. J Bacteriol. 2012 Jun;194(12):3264-5. doi: 10.1128/JB.00545-12. PubMed PMID: 22628498; PubMed Central PMCID: PMC3370840. 16. McClendon SD, Mao Z, Shin HD, Wagschal K, Chen RR. Designer xylanosomes: protein nanostructures for enhanced xylan hydrolysis. Appl Biochem Biotechnol. 2012 Jun;167(3):395-411. doi: 10.1007/s12010-012-9680-1. Epub 2012 May 4. PubMed PMID: 22555497. 17. Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. ESI LC-MS and MS/MS characterization of antifungal cyclic lipopeptides produced by Bacillus subtilis XF-1. J Mol Microbiol Biotechnol. 2012;22(2):83-93. doi: 10.1159/000338530. Epub 2012 May 16. PubMed PMID: 22614917. 18. Agrawal M, Mao Z, Chen RR. Adaptation yields a highly efficient xylose-fermenting Zymomonas mobilis strain. Biotechnol Bioeng. 2011 Apr;108(4):777-85. doi: 10.1002/bit.23021. Epub 2010 Dec 22. PubMed PMID: 21404252. Liang Y, Li X, Shin H, Chen RR, Mao Z. Expression and characterization of a xylosidase (Bxyl) from Bacillus halodurans C-125. Sheng Wu Gong Cheng Xue Bao. 2009 Sep;25(9):1386-93. PubMed PMID: 19938483. 19. Mao Z, Shin HD, Chen R. A recombinant E. coli bioprocess for hyaluronan synthesis. Appl Microbiol Biotechnol. 2009 Aug;84(1):63-9. doi: 10.1007/s00253-009-1963-2. Epub 2009 Mar 24. PubMed PMID: 19308402. 20. Mao Z, Chen RR. Recombinant synthesis of hyaluronan by Agrobacterium sp. Biotechnol Prog. 2007 Sep-Oct;23(5):1038-42. doi: 10.1021/bp070113n. Epub 2007 Aug 18. PubMed PMID: 17705506. 21. Ni Y, Mao Z, Chen RR. Outer membrane mutation effects on UDP-glucose permeability and whole-cell catalysis rate. Appl Microbiol Biotechnol. 2006 Nov;73(2):384-93. doi: 10.1007/s00253-006-0485-4. Epub 2006 Sep 27. PubMed PMID: 17004054. Ruffing A, Mao Z, Ruizhen Chen R. Metabolic engineering of Agrobacterium sp. for UDP-galactose regeneration and oligosaccharide synthesis. Metab Eng. 2006 Sep;8(5):465-73. doi: 10.1016/j.ymben.2006.05.004. Epub 2006 Jun 7. PubMed PMID: 16890004. 22. Mao Z, Shin HD, Chen RR. Engineering the E. coli UDP-glucose synthesis pathway for oligosaccharide synthesis. Biotechnol Prog. 2006 Mar-Apr;22(2):369-74. doi: 10.1021/bp0503181. PubMed PMID: 16599548.