姓名：毛自朝

职称： 教授

导师：硕士生导师、博士生导师

专业：作物生物学

邮箱：zmao@ynau.edu.cn

■  教育经历

u  2004-09 至 2009-09, 分别在美国弗吉尼亚联邦大学（VCU）和佐治亚理工大学 (GIT)从事基因代谢工程方面的博士后研究

◆  1999-09 至 2002-07, 北京大学, 植物学, 博士

◆  1992-09 至 1995-07, 中国科学院昆明植物研究所, 植物学, 硕士

◆  1988-09 至 1992-07, 兰州大学, 植物学, 学士

■  工作经历

◆  2010-10 至今, 云南农业大学, 农学与生物技术学院, 教授

◆  2002-10 至 2010-10, 云南农业大学, 农学与生物技术学院, 副教授

◆  1997-10 至 2002-10, 云南农业大学, 农学与生物技术学院, 讲师

◆  1995-07 至 1997-10, 云南农业大学, 农学与生物技术学院, 助教

■  教学

承担研究生《组学与数据分析》,《分子生物学与基因组学》和《基因组学与分子设计育种》、本科生《基因组学》、《生物技术专业英语》等课程的教学任务

■  研究方向

基因组学与分子生物学

■  奖励与荣誉

u 云南省技术创新人才

u 全国农业生物化学与分子生物学学会农业分会理事

u 中国园艺学会芦笋分会理事

u 云南省高等学校大学课程教学指导委员会成员

■  研究项目

◆  主持国家基金项目3项；

◆  国家中小企业创新基金1项；

◆  国际合作项目、省级及其他横向项目等20余项

■  代表性论文

u  Cheng Q, Zeng L, Wen H, Brown SE, Wu H, Li X, Lin C, Liu Z, Mao Z.Steroidal saponin profiles and their key genes for synthesis and regulation in Asparagus officinalis L. by joint analysis of metabolomics and transcriptomics.BMC Plant Biol. 2023 20;23(1):207. doi: 10.1186/s12870-023-04222-x.PMID: 37081391. 

u  Lin C, Huang Q, Liu Z, Brown SE, Chen Q, Li Y, Dong Y, Wu H, Mao Z.Gene. 2023 AoSAP8-P encoding A20 and/or AN1 type zinc finger protein in asparagus officinalis L. Improving stress tolerance in transgenic Nicotiana sylvestris. Gene. 2023，862:147284. doi: 10.1016/j.gene.2023.147284

u  Li X, Li M, Mao Z, Du Y, Brown S, Min X, Zhang R, Zhong Y,   Dong Y, Liu Z, Lin C. Identification   of Bioactive Components of Stephania epigaea Lo and Their Potential   Therapeutic Targets by UPLC-MS/MS and Network Pharmacology. Evid Based Complement Alternat Med. 2022;2022:3641586. doi:   10.1155/2022/3641586. eCollection 2022. PubMed PMID: 35529936;   PubMed Central PMCID: PMC9068296.

u  Yang Z, Liu G, Zhang G, Yan J, Dong Y, Lu Y, Fan W, Hao B,   Lin Y, Li Y, Li X, Tang Q, Xiang G, He S, Chen J, Chen W, Xu Z, Mao Z, Duan   S, Jin S, Yang S. The   chromosome-scale high-quality genome assembly of Panax notoginseng provides   insight into dencichine biosynthesis. Plant Biotechnol J. 2021 May;19(5):869-871. doi:   10.1111/pbi.13558. Epub 2021 Feb 14. PubMed PMID: 33529371; PubMed   Central PMCID: PMC8131050.

u  Zhang G, Mao Z, Wang Q, Song J, Nie X, Wang T, Zhang H, Guo   H. Comprehensive   transcriptome profiling and phenotyping of rootstock and scion in a   tomato/potato heterografting system. Physiol   Plant. 2019 Jul;166(3):833-847. doi: 10.1111/ppl.12858. Epub   2018 Nov 15. PubMed PMID: 30357855.

u  Harkess A, Zhou J, Xu C, Bowers JE, Van der Hulst R,   Ayyampalayam S, Mercati F, Riccardi P, McKain MR, Kakrana A, Tang H, Ray J,   Groenendijk J, Arikit S, Mathioni SM, Nakano M, Shan H, Telgmann-Rauber A,   Kanno A, Yue Z, Chen H, Li W, Chen Y, Xu X, Zhang Y, Luo S, Chen H, Gao J,   Mao Z, Pires JC, Luo M, Kudrna D, Wing RA, Meyers BC, Yi K, Kong H, Lavrijsen   P, Sunseri F, Falavigna A, Ye Y, Leebens-Mack JH, Chen G. The asparagus genome sheds light on the origin and   evolution of a young Y chromosome. Nat   Commun. 2017 Nov 2;8(1):1279. doi:   10.1038/s41467-017-01064-8. PubMed PMID: 29093472; PubMed Central PMCID:   PMC5665984.

u  Anane RF, Sun H, Zhao L, Wang L, Lin C, Mao Z. Improved curdlan production with discarded bottom parts   of Asparagus spear. Microb Cell   Fact. 2017 Apr 7;16(1):59. doi:   10.1186/s12934-017-0671-3. PubMed PMID: 28388915; PubMed Central PMCID:   PMC5384130.

u  Li XM, Cai JL, Wang L, Wang WX, Ai HL, Mao ZC. Two new phenolic compounds and antitumor activities of   asparinin A from Asparagus officinalis. J Asian Nat Prod Res. 2017 Feb;19(2):164-171. doi:   10.1080/10286020.2016.1206529. Epub 2016 Sep 13. PubMed PMID:   27618876.

u  Li XM, Cai JL, Wang WX, Ai HL, Mao ZC. Two new acetylenic compounds from Asparagus   officinalis. J Asian Nat Prod   Res. 2016;18(4):344-8. doi:   10.1080/10286020.2015.1082549. Epub 2015 Nov 11. PubMed PMID:   26558641.

u  Yu X, Zhang C, Yang L, Zhao L, Lin C, Liu Z, Mao Z. CrdR function in a curdlan-producing Agrobacterium sp.   ATCC31749 strain. BMC   Microbiol. 2015 Feb 10;15:25. doi:   10.1186/s12866-015-0356-1. PubMed PMID: 25880528; PubMed Central PMCID:   PMC4327974.

u  Li XY, Yang JJ, Mao ZC, Ho HH, Wu YX, He YQ. Enhancement of Biocontrol Activities and Cyclic   Lipopeptides Production by Chemical Mutagenesis of Bacillus subtilis XF-1, a   Biocontrol Agent of Plasmodiophora brassicae and Fusarium solani. Indian J Microbiol. 2014 Dec;54(4):476-9. doi:   10.1007/s12088-014-0471-y. Epub 2014 May 23. PubMed PMID: 25320450;   PubMed Central PMCID: PMC4186944.

u  Rutter C, Mao Z, Chen R. Periplasmic   expression of a Saccharophagus cellodextrinase enables E. coli to ferment   cellodextrin. Appl Microbiol   Biotechnol. 2013 Sep;97(18):8129-38. doi: 10.1007/s00253-012-4646-3. Epub   2013 Jan 10. PubMed PMID: 23306638.

u  Chen RR, Agrawal M, Mao Z. Impact   of expression of EMP enzymes on glucose metabolism in Zymomonas   mobilis. Appl Biochem   Biotechnol. 2013 Jun;170(4):805-18. doi:   10.1007/s12010-013-0239-6. Epub 2013 Apr 24. PubMed PMID: 23613118.

u  Guo S, Mao Z, Wu Y, Hao K, He P, He Y. Genome Sequencing of Bacillus subtilis Strain XF-1 with   High Efficiency in the Suppression of Plasmodiophora brassicae. Genome Announc. 2013 Apr 4;1(2):e0006613. doi:   10.1128/genomeA.00066-13. PubMed PMID: 23558530; PubMed Central PMCID:   PMC3622977.

u  Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. Diversity and active mechanism of fengycin-type   cyclopeptides from Bacillus subtilis XF-1 against Plasmodiophora   brassicae. J Microbiol   Biotechnol. 2013 Mar;23(3):313-21. doi:   10.4014/jmb.1208.08065. PubMed PMID: 23462003.

u  He P, Hao K, Blom J, Rückert C, Vater J, Mao Z, Wu Y, Hou M,   He P, He Y, Borriss R. Genome   sequence of the plant growth promoting strain Bacillus amyloliquefaciens   subsp. plantarum B9601-Y2 and expression of mersacidin and other secondary   metabolites. J Biotechnol. 2012 Dec   15;164(2):281-91. doi: 10.1016/j.jbiotec.2012.12.014. Epub 2013 Jan   26. PubMed PMID: 23357245.

u  Hao K, He P, Blom J, Rueckert C, Mao Z, Wu Y, He Y, Borriss   R. The   genome of plant growth-promoting Bacillus amyloliquefaciens subsp. plantarum   strain YAU B9601-Y2 contains a gene cluster for mersacidin synthesis. J Bacteriol. 2012 Jun;194(12):3264-5. doi:   10.1128/JB.00545-12. PubMed PMID: 22628498; PubMed Central PMCID:   PMC3370840.

u  McClendon SD, Mao Z, Shin HD, Wagschal K, Chen   RR. Designer   xylanosomes: protein nanostructures for enhanced xylan hydrolysis. Appl Biochem Biotechnol. 2012 Jun;167(3):395-411. doi:   10.1007/s12010-012-9680-1. Epub 2012 May 4. PubMed PMID: 22555497.

u  Li XY, Mao ZC, Wang YH, Wu YX, He YQ, Long CL. ESI LC-MS and MS/MS characterization of antifungal   cyclic lipopeptides produced by Bacillus subtilis XF-1. J Mol Microbiol Biotechnol. 2012;22(2):83-93. doi:   10.1159/000338530. Epub 2012 May 16. PubMed PMID: 22614917.

u  Agrawal M, Mao Z, Chen RR. Adaptation   yields a highly efficient xylose-fermenting Zymomonas mobilis strain. Biotechnol Bioeng. 2011 Apr;108(4):777-85. doi:   10.1002/bit.23021. Epub 2010 Dec 22. PubMed PMID: 21404252.

u  Liang Y, Li X, Shin H, Chen RR, Mao Z. Expression and characterization of a xylosidase (Bxyl)   from Bacillus halodurans C-125. Sheng   Wu Gong Cheng Xue Bao. 2009 Sep;25(9):1386-93. PubMed PMID:   19938483.

u  Mao Z, Shin HD, Chen R. A   recombinant E. coli bioprocess for hyaluronan synthesis. Appl Microbiol Biotechnol. 2009 Aug;84(1):63-9. doi:   10.1007/s00253-009-1963-2. Epub 2009 Mar 24. PubMed PMID: 19308402.

u  Mao Z, Chen RR. Recombinant   synthesis of hyaluronan by Agrobacterium sp. Biotechnol Prog. 2007 Sep-Oct;23(5):1038-42. doi:   10.1021/bp070113n. Epub 2007 Aug 18. PubMed PMID: 17705506.

u  Ni Y, Mao Z, Chen RR. Outer   membrane mutation effects on UDP-glucose permeability and whole-cell   catalysis rate. Appl Microbiol   Biotechnol. 2006 Nov;73(2):384-93. doi:   10.1007/s00253-006-0485-4. Epub 2006 Sep 27. PubMed PMID: 17004054.

u  Ruffing A, Mao Z, Ruizhen Chen R. Metabolic   engineering of Agrobacterium sp. for UDP-galactose regeneration and   oligosaccharide synthesis. Metab   Eng. 2006 Sep;8(5):465-73. doi:   10.1016/j.ymben.2006.05.004. Epub 2006 Jun 7. PubMed PMID:   16890004.

u  Mao Z, Shin HD, Chen RR. Engineering   the E. coli UDP-glucose synthesis pathway for oligosaccharide   synthesis. Biotechnol Prog. 2006   Mar-Apr;22(2):369-74. doi: 10.1021/bp0503181. PubMed PMID:   16599548.